Nitric oxide signaling mechanisms in the forearm vasculature of pregnant women.

Anumba, D O; Ford, G A; Robson, S C · Am J Obstet Gynecol · 2001

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Abstract

During pregnancy, forearm blood flow and constrictor responses to nitric oxide synthase inhibition are enhanced. Responses to brachial artery infusion of N(G)-monomethyl-L -arginine in pregnant women who have normal resting forearm blood flow and in pregnant women who have norepinephrine-induced reduced forearm blood flow were no different. Mechanisms independent of acute flow effects may account for the enhanced vascular nitric oxide activity during pregnancy.

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