Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: evidence of molecular mimicry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 11524496.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain-Barré syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.
Medical subject headings
- Autoantibodies
- Galactosylceramides
- Guillain-Barre Syndrome
- Molecular Mimicry
- Pneumonia, Mycoplasma