Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients.
prospective_cohort · Level II
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Abstract
In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.
Medical subject headings
- Alzheimer Disease
- Aspartic Acid
- Cognition Disorders
- Creatine
- Temporal Lobe