Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome.
basic_science · Level V
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Abstract
We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.
Medical subject headings
- Anemia, Sideroblastic
- DNA, Mitochondrial
- In Situ Hybridization, Fluorescence
- Pancreatic Diseases