Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users.
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Abstract
Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.
Medical subject headings
- Analgesics, Opioid
- Anti-HIV Agents
- HIV Infections
- HIV-1
- Methadone
- Nevirapine
- Reverse Transcriptase Inhibitors
- Substance Abuse, Intravenous