Cracking the transcriptional code for cell specification in the neural tube.
basic_science · Level V
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- Record sourced from PubMed, PMID 11572771.
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Abstract
The bHLH repressor Olig2 participates in the transcriptional code governing cell fate specification in the ventral spinal cord. By temporally selective interactions with other transcription factors, Olig2 first directs motor neuron fate and later switches to promoting oligodendrocyte production.
Medical subject headings
- Central Nervous System
- Nerve Tissue Proteins
- Neuroglia
- Neurons
- Spinal Cord
- Transcription, Genetic