Opening of the clamp: an intimate view of an ATP-driven biological machine.
review · Level V
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- Record sourced from PubMed, PMID 11572772.
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Abstract
DNA polymerases require tethering to an accessory factor, typically a ring-shaped clamp, to remain bound to DNA during replication. Three recent structural studies provide unique insight into how these clamps are loaded onto DNA by the clamp loader machinery.
Medical subject headings
- Adenosine Triphosphate
- DNA
- DNA Replication
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase