HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 11595178.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
Medical subject headings
- Caenorhabditis elegans Proteins
- Cell Hypoxia
- DNA-Binding Proteins
- Nuclear Proteins
- Oxygen
- Procollagen-Proline Dioxygenase
- Signal Transduction
- Transcription Factors