Deamidation of human proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 11606750.
- Also identified by PMC identifier 60067.
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Abstract
Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.
Medical subject headings
- Proteins