Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes.
case_report · Level V
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Abstract
We describe a patient in whom pemphigus foliaceus developed after cutaneous squamous cell carcinoma (SCC) metastasized to regional lymph nodes. Immunologic analysis revealed that production of anti-desmoglein 1 autoantibodies started when SCC metastasized, and the SCC expressed desmoglein 1, suggesting a pathogenic role of metastasized SCC in developing pemphigus foliaceus.
Medical subject headings
- Cadherins
- Carcinoma, Squamous Cell
- Lymphatic Metastasis
- Pemphigus
- Skin Neoplasms