Anaphylactoid reactions associated with menstruation affecting two sisters.
case_report · Level V
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- Record sourced from PubMed, PMID 11700834.
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Abstract
Cyclical anaphylactoid reactions associated with menstruation are exceedingly rare. We report two sisters who were both affected, one severely and one mildly. Treatment involved suppression of menstruation and use of a cyclooxygenase-2 (COX-2) inhibitor. An abnormal reaction to prostaglandins, perhaps produced by COX-2 enzyme activity in the endometrium, is a possible mechanism.