Treatment of idiopathic restless legs syndrome (RLS) with gabapentin.

Happe, S; Klösch, G; Saletu, B; Zeitlhofer, J · Neurology · 2001

case_series · Level IV

Where this comes from

Abstract

Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.

Medical subject headings