CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation.
basic_science · Level V
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- Record sourced from PubMed, PMID 11707593.
- Also identified by PMC identifier 61130.
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Abstract
Dim expression of CD5 on human B lymphocytes has been used to delineate B1 and B2 subsets. Nevertheless, others have suggested that the molecule is an activation marker and does not predicate a subset distinction. We have used enzymatic amplification staining, a technology that enhances the resolution of flow cytometric analysis of cell surface molecules by as much as 100-fold, to determine that essentially all human B cells express CD5. Furthermore, we show that this expression is regulated during Epstein-Barr virus transformation.
Medical subject headings
- B-Lymphocytes
- CD5 Antigens
- Gene Expression
- Herpesvirus 4, Human