Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation.

Berven, S; Tay, B K; Kleinstueck, F S; Bradford, D S · Eur Spine J · 2001

review · Level V

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Abstract

Bone graft substitutes may be broadly classified as mineralized and demineralized preparations. This article reviews the basic science and biology underlying each preparation. A review of the clinical and experimental applications of each preparation follows. The text concludes with a review of growth factors as biological supplements.

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