Protein threading by learning.
basic_science · Level V
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- Record sourced from PubMed, PMID 11717394.
- Also identified by PMC identifier 64685.
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Abstract
By using techniques borrowed from statistical physics and neural networks, we determine the parameters, associated with a scoring function, that are chosen optimally to ensure complete success in threading tests in a training set of proteins. These parameters provide a quantitative measure of the propensities of amino acids to be buried or exposed and to be in a given secondary structure and are a good starting point for solving both the threading and design problems.
Medical subject headings
- Proteins