A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst.
basic_science · Level V
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Abstract
One of the many intriguing features of gene silencing by RNA interference is the apparent catalytic nature of the phenomenon. New biochemical and genetic evidence now shows that an RNA-directed RNA polymerase chain reaction, primed by siRNA, amplifies the interference caused by a small amount of "trigger" dsRNA.
Medical subject headings
- Gene Silencing
- RNA, Messenger
- RNA, Untranslated
- RNA-Dependent RNA Polymerase