New glimpses of an old machine.
review · Level V
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- Record sourced from PubMed, PMID 11733056.
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Abstract
Two recent studies illustrate the ability of the Mre11/Rad50 DNA repair complex to bind and connect DNA ends. Specific stimulation of DNA ligase IV-mediated end-joining by Mre11 complexes from S. cerevisiae suggests the possibility of a direct role in nonhomologous end-joining in eukaryotic cells.
Medical subject headings
- DNA
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Saccharomyces cerevisiae Proteins