The unfolding tale of the unfolded protein response.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 11779459.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Medical subject headings
- Protein Folding
- Protein Serine-Threonine Kinases
- Protein Transport
- Saccharomyces cerevisiae Proteins