Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease.
case_series · Level IV
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Abstract
The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.
Medical subject headings
- Creutzfeldt-Jakob Syndrome
- Dinoprost
- Dinoprostone