Anticholinergic drugs: response of parkinsonism not responsive to levodopa.
case_report · Level V
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- Record sourced from PubMed, PMID 11784836.
- Also identified by PMC identifier 1737680.
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Abstract
A 41 year old man with parkinsonism and pyramidal signs is described. He was non-responsive to levodopa and dopamine receptor agonists but dramatically responded to trihexyphenidyl. In this patient, brain MRI showed bilateral hyperintensities along the corticospinal tracts on T2 weighted images. PET studies showed a decrease in (18)F-6-fluorodopa uptake in the putamen contralateral to the more affected limbs and normal D(2) receptor binding in the putamen. The PET and MRI findings and responsiveness to antiparkinsonian agents suggested degeneration of nigrostriatal dopaminergic neurons, striatal output pathways, and corticospinal tracts.
Medical subject headings
- Cholinergic Antagonists
- Levodopa
- Magnetic Resonance Imaging
- Parkinsonian Disorders
- Tomography, Emission-Computed
- Trihexyphenidyl