Life extension in Drosophila by feeding a drug.
basic_science · Level V
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- Record sourced from PubMed, PMID 11792861.
- Also identified by PMC identifier 117392.
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Abstract
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
Medical subject headings
- Drosophila
- Longevity
- Phenylbutyrates