Protein aggregates and dementia: is there a common toxicity?
review · Level V
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- Record sourced from PubMed, PMID 11796764.
- Also identified by PMC identifier 1737746.
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Abstract
This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)--beta-amyloid peptide and tau--but also considers other proteins in this disorder and in less common but equally devastating diseases.
Medical subject headings
- Alzheimer Disease
- Neurodegenerative Diseases
- Proteins