FADD: A link between TNF family receptors and caspases in Parkinson's disease.
basic_science · Level V
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Abstract
Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective vulnerability of nigral DA neurons in PD, suggesting that this pathway contributes to the susceptibility of DA neurons in PD to TNF-mediated apoptosis.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- Parkinson Disease
- Substantia Nigra