Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.
basic_science · Level V
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- Record sourced from PubMed, PMID 11805306.
- Also identified by PMC identifier 122170.
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Abstract
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
Medical subject headings
- Amanitins
- RNA Polymerase II
- Transcription, Genetic