Papillon-Lefevre syndrome: a case report of four affected siblings.

Angel, Tiffany A; Hsu, Sylvia; Kornbleuth, Steven I; Kornbleuth, Joseph; Kramer, E Michael · J Am Acad Dermatol · 2002

case_report · Level V

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Abstract

Four siblings, products of a consanguineous marriage, had palmoplantar keratoderma and loss of teeth. In addition, 3 of the siblings had psoriasiform plaques on their elbows and/or knees and 1 had intracranial calcifications. To our knowledge, this is the second largest reported number of affected members in a family with Papillon-Lefevre syndrome, a rare genodermatosis.

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