Ricardo Miledi and the calcium hypothesis of neurotransmitter release.
basic_science · Level V
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Abstract
Ricardo Miledi has made significant contributions to our basic understanding of how synapses work. Here I discuss aspects of Miledi's research that helped to establish the requirement of presynaptic calcium for neurotransmitter release, from his earliest scientific studies to his classic experiments in the squid giant synapse.
Medical subject headings
- Calcium
- Neurotransmitter Agents
- Synaptic Transmission