Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.
review · Level V
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Abstract
Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.
Medical subject headings
- Disease Models, Animal
- Genetic Predisposition to Disease
- Neoplasms