Apoptosis: a link between cancer genetics and chemotherapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 11832206.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
Medical subject headings
- Antineoplastic Agents
- Apoptosis
- Neoplasms