The role of PML in tumor suppression.
review · Level V
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Abstract
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
Medical subject headings
- Apoptosis
- Cell Transformation, Neoplastic
- Genes, Tumor Suppressor
- Intracellular Signaling Peptides and Proteins
- Neoplasm Proteins
- Oncogene Proteins, Fusion
- Transcription Factors