Airway hyperresponsiveness and calcium handling by smooth muscle: a "deeper look".

Parameswaran, Krishnan; Janssen, Luke J; O'Byrne, Paul M · Chest · 2002

basic_science · Level V

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Abstract

We propose that abnormal calcium handling by the airway smooth muscle may be an important determinant of airway hyperresponsiveness. The amplitude, frequency, or localization of Ca(2+) oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma.

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