Methadone and fluconazole: respiratory depression by drug interaction.
case_report · Level V
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- Record sourced from PubMed, PMID 11844635.
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Abstract
A 60-year-old man with advanced gastric cancer achieved good pain control on a stable dose of methadone for 10 days. However, he developed respiratory depression 2 days after intravenous fluconazole was administrated for refractory oral candidiasis. Intravenous naloxone effectively reversed the respiratory depression. This case illustrates a significant interaction between methadone and fluconazole, and highlights the need for awareness of potential interactions between drugs used in palliative care.
Medical subject headings
- Analgesics, Opioid
- Antifungal Agents
- Fluconazole
- Methadone
- Respiratory Insufficiency