Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations?
case_report · Level V
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Abstract
A boy had infantile-onset systemic inflammation, growth failure, hepatosplenomegaly, anemia, leukocytopenia, progressive muscular dystrophy, and hypercalprotectinemia, resulting in marked hyperzincemia. His mother had a history of chronic arthritis since childhood and also showed hypercalprotectinemia/hyperzincemia. We postulate an inherent defect in calprotectin metabolism.
Medical subject headings
- Arthritis, Juvenile
- Calcium-Binding Proteins
- Membrane Glycoproteins
- Metabolism, Inborn Errors
- Neural Cell Adhesion Molecules
- Zinc