CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 11865444.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
CD40 and CD154 (CD40 ligand) are surface molecules that are central to the cross-talk between T cells and antigen-presenting cells. This article reviews the relevance of CD40-CD154 interaction for regulation of interleukin-12/interferon-gamma production in response to Toxoplasma gondii as an example of an intracellular pathogen. The manner in which defects in CD154 signaling contribute to immunosuppression and susceptibility to opportunistic infections in patients with X-linked hyper IgM syndrome and in patients with human immunodeficiency virus infection is also discussed.
Medical subject headings
- CD40 Antigens
- CD40 Ligand
- HIV Infections
- Immunologic Deficiency Syndromes
- Interferon-gamma
- Interleukin-12