Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus.
basic_science · Level V
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- Record sourced from PubMed, PMID 11891318.
- Also identified by PMC identifier 122592.
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Abstract
Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.
Medical subject headings
- Chromosomes, Human, Pair 4
- Electroencephalography
- Linkage Disequilibrium
- Quantitative Trait, Heritable
- Receptors, GABA-A