Microbial minimalism: genome reduction in bacterial pathogens.
review · Level V
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- Record sourced from PubMed, PMID 11893328.
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Abstract
When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts.
Medical subject headings
- Bacteria
- Genome, Bacterial