Helicobacter pylori and gastrointestinal tract adenocarcinomas.
review · Level V
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- Record sourced from PubMed, PMID 11902583.
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Abstract
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Medical subject headings
- Adenocarcinoma
- Gastrointestinal Neoplasms
- Helicobacter Infections
- Helicobacter pylori