Actin' up: RhoB in cancer and apoptosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 11905808.
- Also identified by DOI 10.1038/35101096.
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Abstract
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.
Medical subject headings
- Actins
- Apoptosis
- Neoplasms
- rhoB GTP-Binding Protein