The RNA polymerase II machinery: structure illuminates function.

Woychik, Nancy A; Hampsey, Michael · Cell · 2002

basic_science · Level V

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Abstract

Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.

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