Combinatorial control of gene expression by nuclear receptors and coregulators.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 11909518.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in response to endocrine signaling, and recruitment of coregulators affords these receptors considerable functional flexibility. We will place historical aspects of NR research in context with current opinions on their mechanism of signal transduction, and we will speculate upon future trends in the field.
Medical subject headings
- Gene Expression Regulation
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
- Transcription, Genetic