Integrating mRNA processing with transcription.
review · Level V
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- Record sourced from PubMed, PMID 11909521.
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Abstract
The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.
Medical subject headings
- RNA Polymerase II
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- Transcription, Genetic