A conserved mRNA export machinery coupled to pre-mRNA splicing.
review · Level V
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Abstract
Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.
Medical subject headings
- Active Transport, Cell Nucleus
- Nuclear Proteins
- RNA Precursors
- RNA Splicing
- RNA, Messenger
- RNA-Binding Proteins