Emergence of multiple drug-resistant human cytomegalovirus variants in 2 patients with human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy.
case_report · Level V
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Abstract
In 2 patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy was unable to suppress HIV replication as a result of the emergence of drug-resistant HIV variants. Human cytomegalovirus (HCMV) retinitis developed in both patients, and an unusually complex mixture of drug-resistant HCMV variants was detected in both patients.
Medical subject headings
- AIDS-Related Opportunistic Infections
- Cytomegalovirus
- Cytomegalovirus Retinitis
- Drug Resistance, Multiple
- HIV Infections