Interleukin-2 in the pathogenesis of perinatal white matter damage.
basic_science · Level V
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Abstract
Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.
Medical subject headings
- Brain
- Infant, Newborn
- Infant, Premature
- Interleukin-2