Osteochondromatosis with high concentration of procollagen II C peptide in joint fluid.

Kobayashi, Tatsuo; Fujikawa, Kyosuke; Sasazaki, Yoshihiro; Aoki, Yoshihiro · Knee · 2002

case_report · Level V

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Abstract

Procollagen II C peptide is used as a joint fluid marker of collagen synthesis by chondrocytes in patients with osteoarthritis. Since osteochondromatosis activates ectopic chondrogenesis in the synovial membrane, procollagen II C peptide is expected to be a good marker of the disease. Procollagen II C peptide can be used to evaluate the condition of the disease metabolically by simply aspirating the joint fluid. We have experienced a case of osteochondromatosis (Miligram's stage 2) with a high concentration of procollagen II C peptide. This case suggests that the concentration of procollagen II C peptide is a good marker of chondrogenesis by osteochondromatosis.

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