Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?
basic_science · Level V
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- Record sourced from PubMed, PMID 11955439.
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Abstract
When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)), the recently discovered dsDNA break repair protein named Artemis acquires the ability to open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a physiological role for this complex as the elusive hairpin-opening activity in V(D)J recombination.
Medical subject headings
- DNA
- DNA Ligases
- DNA Nucleotidyltransferases
- DNA Repair
- Nuclear Proteins
- Recombination, Genetic
- beta-Lactamases