Paroxysmal episodic central thermoregulatory failure.

Magnifico, F; Pierangeli, G; Barletta, G; Candela, C; Montagna, P; Bonavina, G; Cortelli, P · Neurology · 2002

case_report · Level V

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Abstract

A 51-year-old man presenting with paroxysmal attacks of unilateral sweating for 1 year was studied. Clinical and laboratory findings made the diagnosis of Shapiro or Harlequin syndrome unlikely. The onset of the sweating "crisis" was immediately followed by a progressive decrease in rectal and skin temperature, lasting for about 2 hours. This indicated that hypothermia was related to an abnormal downward shift of the thermoregulatory set point and a delayed effect of mechanisms blocking heat dissipation.

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