Genetic control of MHC class II expression.
basic_science · Level V
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- Record sourced from PubMed, PMID 11983150.
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Abstract
The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression.
Medical subject headings
- Gene Expression Regulation
- Genes, MHC Class II
- Nuclear Proteins