Missing pieces in the NF-kappaB puzzle.
review · Level V
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- Record sourced from PubMed, PMID 11983155.
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Abstract
The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.
Medical subject headings
- NF-kappa B