DNA and its associated processes as targets for cancer therapy.
review · Level V
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Abstract
DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?
Medical subject headings
- Antineoplastic Agents
- DNA
- DNA, Neoplasm
- Neoplasms