Oncogenic resistance to growth-limiting conditions.
review · Level V
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- Record sourced from PubMed, PMID 11990858.
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Abstract
Many carcinogens are mutagens, indicating that mutagenesis is the driving force of carcinogenesis. But what if we turn this prevailing view on its head? I will argue here that carcinogens are cytostatic and/or cytotoxic, and it is not mutation per se, but clonal selection for resistance to these antiproliferative conditions, that leads to cancer. But why aren't all cytotoxins carcinogenic?
Medical subject headings
- Cell Transformation, Neoplastic